George W. Wilkinson was an American politician.
He moved to Bloomington Township, Muscatine County, Iowa, where he was a farmer.
He lived with his wife Mary, a Pennsylvania native born in 1825.
Wilkinson was elected to the Iowa Senate as a Whig from District 17.
Prior to the 1856 Iowa Senate election, Wilkinson was redistricted to District 19 and joined the Know Nothings.