George Worthington (October 14, 1840 – January 7, 1908) was the second bishop of Nebraska in The Episcopal Church.

He worked as a bookkeeper for his uncle and later studied at Hobart College (now part of Hobart and William Smith Colleges), graduating with a Bachelor of Arts in 1860, and awarded a Doctor of Divinity in 1876, and a Doctor of Laws in 1885.

Due to his heart condition, Worthington was unable to remain in the high altitude of Nebraska, and consequently moved to Pittsfield, Massachusetts, in 1890, while the diocese was administered by his coadjutor, and eventual successor, Arthur Llewllyn Williams.

In May 1907, Worthington was appointed Bishop of the Convocation of Episcopal Churches in Europe, after which he moved to France.

His body was identified by his wife a day later, as he had no identification papers at the time of his death.