Georges-Isidore Barthe (November 16, 1834 – August 11, 1900) was a Quebec lawyer, publisher, journalist, and political figure.
He was born Isidore Barthe in Restigouche (now Listuguj Mi'gmaq First Nation), Lower Canada, in 1834 and studied at the Séminaire de Nicolet.
Barthe was elected to represent Richelieu in an 1870 by-election after the death of Thomas McCarthy; he was defeated in 1872 but reelected in 1874.
In 1894, he founded L'Indépendance canadienne which advocated a more decentralized Canadian union.
His brother Joseph-Guillaume was also a lawyer and journalist and was a member of the Legislative Assembly of the Province of Canada.