The 69-mile-long (111 km) route connects US 27/SR 1 in Carrollton and Interstate 75 (I-75) in Cartersville.

In extreme eastern Haralson County, the route begins a concurrency with SR 120 traveling east, then travels concurrent with SR 101 northward.

North of Yorkville, SR 101/SR 113 also travels concurrent with US 278/SR 6 to Rockmart.

After crossing the Etowah River, the highway travels through downtown Cartersville as Main Street, before reaching its northern terminus at I-75 in the eastern part of Cartersville.

It is also signed as an east–west highway at its northern terminus at I-75.