Northeast of Thomson is an interchange with Interstate 20 (I-20; Carl Sanders Highway).

Between I-20 and the unincorporated community of Pollards Corner, SR 150 travels along the McDuffie–Columbia county line.

It continues to the northeast to a five-way intersection in Pollards Corner with U.S. Route 221 (US 221) and the western terminus of SR 104 (Washington Road), SR 47 splits off to travel concurrently with US 221 south, while SR 150 splits off to travel concurrent with US 221 north.

SR 150 follows US 221 until they reach the South Carolina state line, where US 221 crosses over the Clarks Hill Dam and continues northeast to Clarks Hill.

[1] From Thomson to Pollards Corner, SR 150 is known as Cobbham Road.