This highway, along with U.S. Route 78 (US 78), connect three of the biggest metro areas of the state together: Atlanta, Athens, and Augusta.

It curves to the northeast and has an incomplete interchange with SR 42 Connector, which acts like an eastern spur of the Freedom Parkway.

The six highways travel together until they reach the southern edge of Deepdene Park, where US 278/SR 10 depart the concurrency to the southeast.

The short Mountain Drive segment of SR 10 passes north of the Kensington MARTA station.

The concurrency enters Snellville, where they intersect SR 124 (Scenic Highway) at the James D. Mason Memorial Interchange.

After passing north of Timothy Road Elementary School, they have an incomplete interchange with the northern terminus of Epps Bridge Parkway.

Just over five blocks later, they skirt along the northern edge of the University of Georgia and curve to the southeast, crossing over the North Oconee River.

Approximately 1,000 feet (300 m) before leaving the city limits, SR 77 departs the concurrency to the north-northeast on Elberton Road.

Southeast of the University of Georgia Farm Lake, the highways cross over Dry Fork Creek into Wilkes County.

In the city, just west of the intersection with the northern terminus of Campbell Street, the mainline routes begin to curve to the east-southeast.

They curve to the south-southeast and travel through rural areas of the county and skirt along the northeastern edge of the Washington–Wilkes Country Club.

Just after they intersect Stagecoach Road, they skirt along the eastern edge of Belle Meade Country Club and then the Thomson–McDuffie County Airport.

They leave the unmarked city limits and curve to the east, before coming back to the south-southeast and intersect SR 223 (White Oak Road).

The concurrency curves to the northeast and then back to the east-southeast, before they cross over Boggy Gut Creek and enter Columbia County.

Just to the southeast of West Boundary Street, they travel about two and a half blocks south of Harlem Middle School.

At the southeastern edge of the city limits, the roadway becomes known as Gordon Highway, which is a major urban corridor farther to the east.

A few thousand feet later, they curve to the northeast, entering Richmond County (and the city limits of Augusta), and begin paralleling the northern edge of Fort Eisenhower.

[1] US 78/US 278/SR 10 serve as the access point for Gordon Park Speedway and Augusta State Medical Prison.

About halfway between here and the interchange with I-520 (Bobby Jones Expressway), the three highways leave the edge of Fort Eisenhower and begin to transition into an urban corridor.

After the interstate, the roadway enters the main part of Augusta, traveling south of Aquinas High School, and curves to the south-southeast, past the location of the now-closed Regency Mall.

A short distance later, they travel to the east of Old Medical College and the Old Government House, then they have an interchange with US 25 Business/SR 28 (Broad Street).

At the state line, SR 10 end, while US 1/US 25/US 78/US 278, concurrent with SC 121 curve to the northeast toward North Augusta.

[2] By the end of 1921, SR 45 was extended from Loganville west-southwest to Decatur and northeast from Monroe to the Bogart area.

In Athens, US 29/US 78/SR 8/SR 10 traveled into the main part of town, with US 29 splitting off onto US 129/US 441 Temporary/SR 15 (Milledge Avenue; now SR 15 Alternate).

[49][50] Between 1994 and 1996, the portion of US 78 between the Bogart area and the northwest of Athens was redesignated as a westward extension of US 78 Business, with SR 10 still along this segment.

[50][51] The Freedom Parkway portion of SR 10 uses the right-of-way of a canceled inner-city Interstate highway project, I-485, which would have traveled eastward (and in a later routing, northward) from downtown Atlanta to an interchange with I-85.

Community opposition ended plans for roadway construction in the 1970s when Jimmy Carter was governor of Georgia, but only after hundreds of homes has already been taken by eminent domain and demolished.

is a 4.0-mile-long (6.4 km) business route of SR 10 that exists almost entirely within the central city limits of Monroe, in Walton County.

The business route passes south of Rest Haven Cemetery and curves to the northeast to meet its eastern terminus, another incomplete interchange with US 78/SR 10.

is a 4.6-mile-long (7.4 km) business route of SR 10 that exists almost entirely within the central city limits of Washington, in Wilkes County.