It heads northeast and curves to the east, to an intersection with SR 39, at the northwest corner of Seminole State Park.

SR 253 continues heading northeast, past Reynoldsville State Park, into Decatur County, and over a northern branch of Lake Seminole, until it meets SR 310 (Yates Spring Road).

[1] In Bainbridge, it meets SR 253 Spur (Airport Road), before it crosses under US 27/US 84/SR 1/SR 38 (Wiregrass Georgia Parkway).

The route then leaves the city to continue to the northeast, passing through rural areas, and crossing into Baker County, before meeting its northern terminus, an intersection with SR 91, southwest of Newton.

It heads north to meet its northern terminus, an intersection with US 84/SR 38, northwest of downtown Bainbridge.