The northern segment is located in the northeastern corner of the Chattooga River District of the Chattahoochee–Oconee National Forest.

SR 28's southern segment begins where SC 28 meets the state line on the Furys Ferry Bridge, northwest of Martinez.

It travels through rural areas of Columbia County and passes Jones Creek Golf Course before entering Martinez.

There, SR 28 passes by West Lake Country Club and continues to the southeast.

It skirts along the northeastern part of Augusta National Golf Club, where the Masters Tournament is held every spring.

At a partial interchange with the western terminus of Broad Street, the Washington Road name ends and the John C. Calhoun Expressway designation begins.

It travels under Milledge Road and has a split diamond interchange with Eve Street and Crawford Avenue.

During a slight southerly jog, the local street name transitions to Sand Bar Ferry Road.

SR 28 travels to the southeast and has an interchange with I-520 (Bobby Jones Expressway) and Laney Walker Boulevard.

It curves to the south-southeast and intersects the eastern terminus of Laney Walker Boulevard Extension; then, the road curves to the east and again meets the South Carolina state line, where the road crosses over the Savannah River on the Sand Bar Ferry Bridge and continues, again as the southern segment of SC 28, and retains the Sand Bar Ferry Road name.

[1] The northern segment of SR 28 is a 7.9-mile-long (12.7 km) highway entirely located in Rabun County.

It immediately enters the Chattooga River District of the Chattahoochee–Oconee National Forest in the southeastern part of Rabun County.

There, it curves to the west-southwest and meets the western terminus of Warwoman Road, which leads to Clayton.

At the western terminus of Firehouse Lane, it passes the Satolah Volunteer Fire Department.

It curves back to the north-northwest and crosses over Talley Mill Creek and travels through Satolah.

[3][4] Between September 1938 and July 1939, the entire length of the northern segment had a completed hard surface.

The project will start with the Furys Ferry Bridge at the South Carolina state line all the way to Evans-to-Locks Road.