The highway acts as a partial bypass of Monticello.

Immediately, the route crosses over a Norfolk Southern Railway line and travels to the southeast.

The route curves to the south-southeast and back to the southeast.

It passes north of Malone Lake before curving to the east and intersecting SR 11 south of the town.

[1] SR 380 is not part of the National Highway System, a system of roadways important to the nation's economy, defense, and mobility.