It connects Glennville with the South Carolina state line, via Claxton, Statesboro, Dover, and Sylvania.

The three highways pass Groover Pond and then enter the south-central part of Evans County.

Just past this community, they pass Evans County Fire Rescue Station No.

In downtown, they cross over some railroad tracks of Georgia Central Railway and then intersect US 280/SR 30/SR 129 (Main Street, also known as Albert Parker Highway).

They pass Smith Transitional Center, the Women's Probation Detention Center, and the Evans County Maintenance Facility, before intersecting the northern terminus of an entrance road to the Claxton Poultry Farms.

Just after curving back to the north-northeast, they pass Lewis Pond and cross over Rocky Branch.

After passing Beasley Pond and crossing over Thick Creek, the highways curve to the north.

US 25, US 301, and SR 73 immediately curve back to the north-northwest and cross over Scott Creek.

They curve back to the north-northwest and have an interchange with Interstate 16 (I-16; Jim Gillis Highway).

After curving to the northeast, they cross over Lotts Creek and then begin paralleling some railroad tracks of Norfolk Southern Railway (NS).

A short distance later, they meet the northern terminus of Parrish Drive, which also leads to GSU.

At this intersection, they begin paralleling the eastern edge of W. Jones Lane Memorial Park.

The four highways intersect Grady Street, which leads to the city's police and fire departments.

An intersection with the eastern terminus of Bulloch Street leads to the Statesboro–Bulloch County Recycling Center.

Just south of an intersection with the eastern terminus of Elm Street, the concurrency curves to the north-northwest.

At an intersection with Parrish Street, US 301 and SR 73 turn right and travel to the east-northeast and make a very gradual curve to the northeast.

Just before an intersection with the southern terminus of Mathews Road, they cross over the NS railroad line.

Almost immediately after entering Sylvania, they intersect the southern terminus of Waters Station Road.

This intersection is the southern terminus of SR 73 Loop, which is US 301's companion state highway through most of the Sylvania area.

At an intersection with South Main Street, where the city hall of Sylvania is located, SR 21 Bus.

SR 73 turns left onto North Main Street and travels to the north-northwest.

Then, they cross over the Savannah River on the Burton's Ferry Bridge, where US 301 enters South Carolina.

A northern segment was also established from SR 24 north of Sylvania northeast to the South Carolina state line.

Between the beginning of 1945 and the end of 1946, it was established from SR 144 in the eastern part of the city to US 25/SR 73 north of it.

[21][14] By February 1948, it was extended southwest, west, and west-northwest to US 25/US 301/SR 23 in the southern part of the city.

), makes up the Veterans Memorial Parkway, which forms a near circle around the southern part of the city.

A short distance later, a frontage road on the eastern side of the roadway joins it.

They pass Screven County Elementary School, with the east frontage road having access to it.

They curve to the north-northeast and intersect Rocky Ford Road, which leads to Screven County's agricultural center, public works department, landfill, and prison, as well as a Georgia State Patrol post, the sheriff's department, and Rocky Ford.

The eastern frontage road ends before they intersect SR 73 (North Main Street).