From Macon to its Savannah, US 80 roughly parallels I-16, taking a more circuitous route to pass through the center several small towns that I-16 bypasses.

The highway crosses the Chattahoochee River from Alabama into Columbus where it proceeds along J. R. Allen Parkway through the northern section of the city as a limited-access freeway.

Beyond Macon, the highway turns southeastward, traveling through the cities of Dublin, where it encircles the Laurens County Courthouse.

At the community of Thunderbolt, where Victory Drive ends, US 80 crosses the Wilmington River and proceeds across the islands and marshes along the Atlantic Coast east of Savannah.

[6] The at-grade intersection at the former southern terminus of the Jimmy DeLoach Parkway was converted into a full diamond interchange.

This portion may eventually be incorporated into the proposed eastern extension of Interstate 14 (I-14), which is currently entirely within Central Texas and may be extended into Augusta.