It exists within portions of Wilkes, Warren, Glascock, Jefferson, and Burke counties.

It connects the Washington area with the northern part of Burke County, via Warrenton, Wrens, and Waynesboro.

It heads south-southeast and crosses over the Little River at the meeting point of Wilkes, Warren, and McDuffie counties.

Just before entering the city limits, it intersects the northern terminus of SR 80 Alternate (VFW Road).

It intersects the western terminus of SR 17 Connector (Purvis School Road) on the Warren–Glascock county line.

was a very short-lived alternate route of SR 80 that existed in the northern part of Burke County.

is a 2.1-mile-long (3.4 km) alternate route that exists entirely within the north central part of Warren County.

It begins at an intersection with US 278/SR 12 (East Main Street), as well as US 278 Byp./SR 12 Byp./SR 80 (Legion Drive), in the east-central part of Warrenton.

The three highways curve to the northeast, cross over some railroad tracks of Norfolk Southern Railway, and intersect the northern terminus of Queens Way.

It heads northwest and curves to a more northerly direction until it meets its eastern terminus, a second intersection with the SR 80 mainline, northeast of Warrenton.