In Pique she met a young Oxford University graduate and English actor (born in Amritsar, Punjab of British India in the British Empire), then 26 year old, Maurice Barrymore (his adopted stage name, born Herbert Arthur Chamberlayne Blyth, 1849-1905), whom she married on December 31, 1876.

[2] They subsequently had three children (two boys and a daughter), all famous film, radio, television stars: Lionel (1878-1954), Ethel (1879-1959), and John Barrymore (1882-1942).

She is also a great-grandmother and partial namesake of popular film / TV actress Drew Barrymore.

Her stage career at this time was being managed by a young up-and-coming producer named Charles Frohman.

Frohman would play a big part in managing the early careers of her three children, as well as her brother John Drew.