She was a regular cast member on Project Runway All Stars (2012–2019) and, together with Keren Craig, is a co-founder of the fashion label Marchesa.

Chapman was married to film producer Harvey Weinstein before leaving him in 2017 in the wake of allegations of sexual abuse against him.

[4] Chapman met future business partner Keren Craig while they both were students at Chelsea College of Art and Design.

[10] In May 2019, Chapman's design for an evening gown was featured in the 2019 Met Gala in New York as worn by Hollywood actress Constance Wu on the runway and staircase for the event.

[15] On 10 October 2017, Chapman announced she was divorcing Weinstein after more than 100 women made accusations of rape, assault, or sexual harassment against him.