Her early research was supervised by Baldwin Spencer and was on Australian fauna, but her later studies were based in the veterinary department working on parasites.

[1] Her work on parasites in Australian native animals and stock led to her being the first woman to win the David Syme Research Prize in 1911, contributing to her reputation as Australia's foremost parasitologist.

[1] She became second-in-charge of the biology school when Thomas Sergeant Hall died in 1915, and from November 1916 to March 1917 she was Australia's first female acting professor when Baldwin Spencer took leave.

The first stone of the Georgina Sweet wing was laid in 1936 and in the following year the first nondenominational hall of residence affiliated with the University opened.

[4] Sweet enjoyed travel and made a journey overland from Cape Town to Cairo with Australian historian Jessie Stobo Watson Webb in 1922.

[1] Some of her bequest to the University was used to establish the Georgina Sweet Bursary, which provides funds to a student of sufficient academic merit who is in special need of financial assistance.