He continued his studies in the schools of Ioannina and subsequently in Bucharest (now capital of Romania, but then part of Wallachia).
In 1804 he began to study philology at the University of Leipzig under Wilhelm Ernst Weber.
In 1820 he returned to Bucharest following an invitation by Prince Alexandros Soutzos of Wallachia and taught in the city’s schools.
[1][page needed] In 1854, during the Crimean War, he led a revolutionary committee for the liberation of Epirus, his homeland, but died the same year during a cholera epidemic.
When he donated his important book collection to the American School of Classical Studies in Athens, the building built to house it was named in honor of Georgios as the Gennadeion.