[1][2][4] His episcopal consecration took place on 20 July 1947,[2] with the Archbishop of Naxos, Tinos, Andros and Mykonos, Giovanni Francesco Filippucci, as principal consecrator, and Archbishop Antonios Grigorios Voutsinos, AA, and Bishop George Calavassy serving as co-consecrators.
[2][4] In 1952, he was additionally appointed apostolic administrator of the Diocese of Crete, a position he held until his death.
[3][5] Regarding the reception of wine through a common chalice, he raised concerns about health and women's lipstick,[3][5] saying:"Today the faithful, especially men, can be seen not to come forward to kiss a sacred relic because, among other things, they fear their lips will be colored by the red marks left by women on the glass of the reliquary.
"[6]Yves Congar, the French Dominican theologian, took notice of Xenopulos at the Council, writing in his book My Journey of the Council about Xenopulos, "the name is Greek, but his pronunciation of Latin was typically and entirely Italian.
He was principal consecrator of Archbishop of Athens Marios Makrionitis in 1953, of Archbishop of Naxos, Tinos, Andros and Mykonos Ioánnis Perrís in 1961, and Bishop of Syros and Santorini Frangiskos Papamanolis, OFM Cap, in 1974.