Debuting in national syndication on October 31, 2005, as a replacement for A Current Affair, the show had been on Fox News Channel in a slightly different format since July 6, 2002 as the program, At Large with Geraldo Rivera.

The program was seen by Rivera as a test for a potential evening newscast produced by the Fox News Channel.

However, the program was more similar to the show that it replaced, A Current Affair, in its focus on tabloid-type stories.

On October 3, 2009, Geraldo at Large began broadcasting in 720p HD and debuted a whole new on-air look, which included a new program logo and new graphics.

On January 4, 2007, it was announced that the syndicated program would be canceled due to a "soft ad marketplace, the lack of an early news lead-in for his show in several cities and the timeline for financial success.