[8] Both games focus on truck/lorry driving in European countries, such as the United Kingdom, Germany, the Czech Republic, Luxembourg, Italy, France, Belgium, the Netherlands, Austria, and Switzerland.

[9][10][11] SCS Software has released a number of maps as downloadable content (DLC) for Euro Truck Simulator 2 .

was released in late 2013, and includes a number of Eastern European countries; adding Hungary and expanding on Slovakia and Poland.

"Iberia",[20] released 8 April 2021, added Spain and Portugal Future plans as of 2023 include "West Balkans" and "Heart of Russia" DLCs, although the latter has been delayed indefinitely due to concerns over the 2022 Russian invasion of Ukraine.

The game currently covers the entire western U.S. states in the lower 48, including part of the south central regions of California, Nevada, Arizona, New Mexico, Oregon, Washington, Utah, Idaho, Colorado, Wyoming, Montana, Texas, Oklahoma, and Kansas.

[22] The game features licensed American conventional trucks; including models by Peterbilt, Kenworth, Volvo, International, Mack, Western Star, and Freightliner.

[31] The state of Montana was released on 4 August 2022 to mark the end of an era to the completion of the entire Western Region in the lower 48.