[3] The vessels have two replenishment at sea stations, one to each per side of the ship and two electro-hydraulic container and cargo cranes.

The MERZ is capable of holding 50 patients and providing them with emergency surgery, intensive care, internal medicine and dental services.

[2] The Berlin-class ships have a helipad aft and a hangar and can support two helicopters, either the Sea King or NH90 models which can be used for vertical replenishment.

[2][7] Her first home port was Kiel,[2] since 26 September 2012, she has been stationed at the Heppenser Groden naval base in Wilhelmshaven.

[8] Frankfurt am Main worked with USS Mesa Verde during mock underway replenishment in the 50th iteration of UNITAS Gold on 26 April 2009.

When reversing in the port, Frankfurt am Main's stern collided with the concrete porch of the lock island.

[12] After returning to service, Frankfurt am Main sailed for the Aegean Sea to join Standing NATO Maritime Group 2, remaining with the unit until March 2018.

MERZ was a containerized-based mobile hospital consisting of 26 containers intended to be flexible to adapt to the navy's needs.

[6][14] After the mobile version's destruction, the navy chose to go with a built-in option, with flexibility diminishing in importance.

They chose Frankfurt am Main to host the new integrierte Marineeinsatz-Rettungszentum (iMERZ) (English: Integrated Marine Rescue Centre).