German submarine U-2354 was a Type XXIII U-boat of Nazi Germany's Kriegsmarine during World War II.

She was ordered on 20 September 1944, and was laid down on 14 October 1944 at Deutsche Werft AG, Hamburg, as yard number 508.

She was launched on 10 December 1944 and commissioned under the command of Oberleutnant zur See Hans-Dieter Wex on 11 January 1945.

The submarine was powered by one MWM six-cylinder RS134S diesel engine providing 575–630 metric horsepower (423–463 kilowatts; 567–621 shaft horsepower), one AEG GU4463-8 double-acting electric motor electric motor providing 580 PS (430 kW; 570 shp), and one BBC silent running CCR188 electric motor providing 35 PS (26 kW; 35 shp).

Of the 156 U-boats that eventually surrendered to the Allied forces at the end of the war, U-2354 was one of 116 selected to take part in Operation Deadlight.