German submarine U-375 was a Type VIIC U-boat built for Nazi Germany's Kriegsmarine for service during World War II.

She was laid down on 14 March 1940 by Howaldtswerke in Kiel as yard number 6, launched on 7 June 1941 and commissioned on 19 July 1941 under Kapitänleutnant Jürgen Koenenkamp.

The submarine was powered by two Germaniawerft F46 four-stroke, six-cylinder supercharged diesel engines producing a total of 2,800 to 3,200 metric horsepower (2,060 to 2,350 kW; 2,760 to 3,160 shp) for use while surfaced, two Garbe, Lahmeyer & Co. RP 137/c double-acting electric motors producing a total of 750 metric horsepower (550 kW; 740 shp) for use while submerged.

[2] The boat's service began on 19 July 1941 with training as part of the 5th U-boat Flotilla.

[1] U-375 was thought to have been sunk after being depth charged by USN submarine chaser PC-624 on 30 July 1943 at position 36°40′N 12°28′E / 36.667°N 12.467°E / 36.667; 12.467 in the Mediterranean NW of Malta.