The German submarine U-387 was a Type VIIC U-boat of Nazi Germany's Kriegsmarine during World War II.

The submarine was powered by two Germaniawerft F46 four-stroke, six-cylinder supercharged diesel engines producing a total of 2,800 to 3,200 metric horsepower (2,060 to 2,350 kW; 2,760 to 3,160 shp) for use while surfaced, two Garbe, Lahmeyer & Co. RP 137/c double-acting electric motors producing a total of 750 metric horsepower (550 kW; 740 shp) for use while submerged.

She followed the Norwegian coast as far as Bodø and then headed due north as far as a point a few miles short of Svalbard.

She then sailed south, passing to the west of Bear Island, docking in Narvik on 21 August.

By now based in Narvik, the submarine was carrying out her seventh patrol when she was attacked by a Norwegian-crewed Sunderland flying boat of No.

On 9 December, she was sunk in the Barents Sea near Murmansk by depth charges dropped by the British corvette HMS Bamborough Castle.