German submarine U-435 was a Type VIIC U-boat built for Nazi Germany's Kriegsmarine for service during World War II.

The submarine was powered by two Germaniawerft F46 four-stroke, six-cylinder supercharged diesel engines producing a total of 2,800 to 3,200 metric horsepower (2,060 to 2,350 kW; 2,760 to 3,160 shp) for use while surfaced, two AEG GU 460/8–27 double-acting electric motors producing a total of 750 metric horsepower (550 kW; 740 shp) for use while submerged.

The straggler Harpalion was finished off after being abandoned having been previously heavily damaged by Luftwaffe Ju 88 dive bombers.

She sank 4 vessels, comprising the minesweeper HMS Leda, RFA fleet oiler Gray Ranger, British Liberty ship Ocean Voice and American freighter Bellingham.

She took part in eleven wolfpacks, namely: She was depth charged and sunk on 9 July 1943 at position 39°48′N 14°22′W / 39.800°N 14.367°W / 39.800; -14.367 west of Figueira, Portugal by a RAF Wellington bomber from 179 Squadron.