Germana Di Natale (born 2 April 1974) is a former professional tennis player from Italy.

A right-handed player, Di Natale started playing tennis at the age of ten and began touring in the early 1990s.

[1] As a professional player she is most noted for her quarterfinal appearance as a qualifier at the 2000 WTA Madrid Open, where she had a win over the top seed Mary Pierce en route.

[2] In the quarterfinals, she had to retire hurt while trailing Iva Majoli by a set due to an injury to her right arm.

[3] During her career, she competed in the qualifying draws of all four Grand Slam tournaments.