It runs from Store Kongensgade in the southeast to Rigensgade in the northwest and is closed to through traffic at Sankt Pauls Plads.

Gernersgade traces its history back to Christian IV's foundation of the Nyboder naval barracks in 1631 but different sections of it were originally known under individual names.

24-44 are examples of the so-called Grey Rows that were built between 1886 and 1893 to design by Olaf Schmidt with inspiration from Arbejdernes Byggeforening's building society houses.

The building was originally constructed as a girls' school for daughters of personnel of the Royal Danish Navy but was later converted into a naval cadet academy and then army barracks.

49-67 were built in 1870–72 by Frederik Bøttger for Arbejdernes Byggeforening to provide affordable, good-quality homes for workers at the B&W shipyard.