She conducted independent research on the "Generation of Electromagnetic Radiation by the Interaction of Charged Particle Beams Transiting Periodic Structures" primarily using the Rutgers University (New Brunswick, NJ) accelerator.

In 1995 Clarke was a panelist with the U.S. Secretary of Education, R. Riley, in a satellite TV program titled Perspectives on Math and Science.

In 1980 Clarke was invited to write an article titled "Teaching physics at Chatham High School"[4] by the editor of The Physics Teacher magazine [5] Clarke has presented invitational lectures at Yale, Wesleyan, Princeton Universities and other collegiate institutions on "The Use of High Energy Particle Beams as a Modality for the Treatment of Localized Cancer".

In addition 13 University research laboratories, several hospitals, the State of New Jersey, and the National Science Foundation were enlisted to contribute financial and human resources.

Clarke directed the NJ BISEC for 18 years, raising millions of dollars to provide training programs designed to improve the quality of teaching.

[2] In 1994 she gave a lecture titled "Medical Applications of High Energy Charged Particles" at the annual Physics Conference and Exploratorium for High School Teachers and Students (March 16, 1994) held at New Jersey Institute of Technology (Newark, NJ)[6] In 1996 Clarke was invited to become a board of trustees member of the New Jersey Inventors Hall of Fame.

With board approval she instituted the prestigious "Trustees Award" which recognized annually one person who has made an outstanding contribution to the inventive and/or innovative process in New Jersey.

The award was presented by P. Roy Vagelos, M.D., chairman and CEO of Merck and Company and John Fowler, PhD, director of the Triangle Coalition for Science and Technology Education.