Gheorghe I. Cantacuzino studied at the Sfântul Sava High School, graduating in 1954.
He then transferred to the Nicolae Minovici Folk Art Museum where he also held a position of museologist from 1961 to 1963.
He then held the position of chief museologist at the National Museum of Romanian History till 1990.
Finally in 1996 he secured a position of scientific researcher at the "Vasile Pârvan" Institute of Archeology of the Romanian Academy.
Gheorghe Cantacuzino is also vice president of the Commission for the History of Cities in Romania (Comisia de Istorie an Oraşelor din România – CIOR) of the Romanian Academy.