Her parents are Peter Taddeo, an Italian American doctor, and Pia, a fruit stand cashier from Italy.

Taddeo completed her Master of Fine Arts in fiction at Boston University.

[7] Taddeo was an associate editor at Golf Magazine when David Granger assigned her first piece for Esquire, titled "The Last Days of Heath Ledger",[8] after reading her unpublished manuscript.

[10] The Washington Post recognized her New York piece, "Rachel Uchitel is Not a Madam",[11] as one of their top five long reads that stand the test of time.

[19] Taddeo's debut novel, Animal, was published by Avid Reader Press in the summer of 2021 and explores themes of "both sisterhood and female rage..."[20] Her third book, Ghost Lover, is a collection of nine short stories published in 2022 by Avid Reader Press.