The film's cast includes Jon Heder, David Krumholtz, Melonie Diaz, Paul W. Downs with Justin Long and Amy Sedaris.

When a customer having "No Trespassing" signs made mentions he owns a barn that might be haunted, Louis recruits a dysfunctional team – his depressed best friend Stan; misfit nephew Zak; a cable access "medium" calling herself Victoria; Ellie, a beautician who works in the same strip mall; and Ross, an overeager security guard – to investigate, partially as an application to join a TV show called Ghost Getters.

While searching for her, Zak, Stan and Ross also disappear, and then Louis and Ellie find the reason: the barn is the home of a meth lab, being run by the sign customer, Mitch, whose employees have been capturing them as trespassers.

Victoria convinces Mitch that she is channeling his father, giving Louis the chance to shoot him with Ross' paintball gun, incapacitating him.

Ghost Team is produced by Julie Christeas and Schuyler Weiss of Tandem Pictures, Alex Sagalchik of Mott Street Pictures, Clem McIntosh and director Oliver Irving, with Kevin Iwashina of Preferred Content serving as Executive Producer.

It was announced on November 12, 2015, that The Orchard and Sony Pictures had acquired North American, U.K., Australian, and New Zealand distribution rights for Ghost Team.