James Roday, Dulé Hill, Timothy Omundson, Maggie Lawson, Corbin Bernsen, and Kirsten Nelson reprised their roles as the main characters.

"I Know, You Know," performed by The Friendly Indians, continued to serve as the theme song for the series, though the Christmas-themed version used for the previous season's "Gus's Dad May Have Killed an Old Guy" was used again for "Christmas Joy."

New directors for the season, directing one episode each, were Jay Chandrasekhar, Martha Coolidge, Michael McMurray, Steve Miner, and series star James Roday.

Andy Berman and Steve Franks returned to write three episodes each, while Josh Bycel, Anupam Nigam, Saladin K. Patterson, and James Roday wrote two.

Chambers, Gary Cole, Barry Corbin, Brooke D'Orsay, Jeff Fahey, Frank Gifford, Milena Govich, Elden Henson, Mickie James, Benjamin King, Emma Lahana, Ted Lange, Jane Lynch, Christopher McDonald, Bruce McGill, Ted McGinley, Ty Olsson, Kelly Overton, Richard Riehle, Shawn Roberts, Alan Ruck, Cassandra Sawtell, Jonathan Silverman, Todd Stashwick, Serinda Swan, Janet Varney, Steven Weber, Christopher Wiehl, and Mykelti Williamson.