Ghotki District (Sindhi: ضِلعو گھوٽڪي; Urdu: ضلع گھوٹکی) is a district of the province of Sindh, Pakistan, with headquarter in the city of Mirpur Mathelo.

Flooded area (Kacha) is stretched on 87 km along Indus River from north - east to south - west of the district where forests exist in this area.

Hinduism (including those from Scheduled Castes) is practiced by 6.35% of the population.

[13] The historic Hindu temple Shadani Darbar is located in this district.

Ghotki District has many historical places, including Mathelo Moomal Ji Mari, where there is a museum and Syed Nathan Shah's (Naharo) tomb.