[3] Giacinto Macripodari was a Greek[2][3][4] born on the Aegean island of Chios, which was part of the Ottoman empire at the time, in 1610.

[3] After he completed his studies Macripodari traveled back to his native Chios where he became vicar and taught at the Dominican monastery.

[3] Several years later the learned Macripodari moved to the Christian quarter of the Ottoman empire's capital, Constantinople, where he soon became vicar of the Dominican monastery.

In 1645 Macripodari became the confessor of the German envoy to Constantinople Alexander von Greiffenklau, this association and support ultimately helped further his career.

He traveled to Vienna where Ferdinand III, Holy Roman Emperor nominated him as the titular bishop of Skopje,[3][4] a post he held from 29 July 1645 to 1649.