Born on 15 December 1517, in Palermo, he was the son of the sculptor Antonello Gagini, and the brother of Fazio and Vincenzo, and half-brother of Giovanni Domenico and Antonino Gagini, all sculptors.
He started to collaborate with his father at an early age, including the work at the Palermo Cathedral.
In 1544, also in the Palermo Cathedral, he sculpted the archbishop's throne, together with his brother Fazio and others.
He also produced numerous works in the province of Palermo (Trapani, Alcamo, Sinagra, Naro, Pettineo).
His autographed and documented works can be found in Palermo, Ciminna, Polizzi Generosa, Caltabellotta, Naro, Sciacca, Castiglione di Sicilia, Randazzo, Calascibetta, Galati Mamertino, Longi, Messina, Mistretta, Montalbano Elicona, Roccella Valdemone, Sinagra, Tortorici, Alcamo, Erice, Marsala, and Trapani.