[7][8] Born in Milan (Italy) to entrepreneur Mario Merello[9] and Italian pop-singer Marcella Bella, Giacomo attended the Catholic Collegio San Carlo[10] High School and Bocconi University in Milan (Italy), achieving a Master of Science in Law (LLM) in 2004.

His name comes from ancestors[11] in the city of Genoa (Italy) and derives from the local genoese term "Merelu" or "wild strawberry".

[12] After practicing civil law within the Studio Baldini in Milan, in 2009 he relocated to the Republic of Singapore,[13] where he setup the international regulatory firm Marvelux Consulting that he currently directs[14] alongside the boutique law firm DMTV,[15] founded by Vietnam and Malta based Prof. Avv.

[16][17][18] Giacomo is professionally known for his legal[19] and regulatory work[20] in the fintech and digital assets spaces,[21] in particular in Singapore, Antigua and Barbuda[22] and in Georgia.

[23] Since 2022, Giacomo Merello is the Chairman of the Digital Assets Business Promotion Board within the Antigua and Barbuda Official Business Hub[24] and, since 2023, he is also Special Economic Envoy of the Commonwealth Realm of Antigua and Barbuda to the Republic of Singapore.