[1][2] On 1 April 1391, he signed an accord with Pope Boniface IX by which he agreed to hand over the Rocca Albornoziana [it] in Spoleto in exchange for the Castello di San Polo [it] in Tivoli, of which he took possession on 21 May.
In 1394, he reached an agreement with his cousin Maria, the heiress of Rinaldo, whereby he inherited the county of Tagliacozzo and the family's other possessions in the Valle dell'Aniene [it] and the Marsica.
In 1404, the queen mother, Margaret of Durazzo, gave him an annual pension of 30 once and the fiefs of Capistrello, Civitella, Civita d'Antino, Meta and Pescocanale [it] in exchange for those of Avezzano and Luco.
[1][3] Ladislaus rival, Duke Louis II of Anjou, who claimed the kingdom, confirmed the detachment of Tagliacozzo and conferred on Orsini the county of Albe.
Although restored to favour in Naples, he recovered Mentana only after a court case that lasted from 1421 to 1424 and after paying compensation in 1426–1427 to Orso's widow, Lorenza Conti, and her minor son, Jacopo Orsini.
[1] Orsini was captured near Faenza on 8 July 1425 while serving the Republic of Florence against the Duchy of Milan during the wars in Lombardy.
He died childless and the county passed to the children of his sister, Girolama, whose husband, Carlo Orsini, was lord of Bracciano.