Giacomo Maria Radini-Tedeschi (12 July 1857 - 22 August 1914) was the Bishop of the Roman Catholic Diocese of Bergamo.

On 5 January 1905 he was named Bishop of the Roman Catholic Diocese of Bergamo by Pope Pius X and consecrated by him in the Sistine Chapel.

Radini-Tedeschi fell ill with cancer and died in the early days of the World War I.

During his episcopal ministry in Bergamo, Radini-Tedeschi had as his secretary a young priest named Angelo Giuseppe Roncalli, who later became Pope John XXIII.

For the late Pope John XXIII, Radini-Tedeschi was a teacher who was never forgotten by his one time follower.