[1] He was consecrated as a bishop on 14 September 1529 in the chapel of San Lorenzo in Piscibus by Cardinal Agostino Spinola.
[1] While Paolo Capizucchi was absent from Rome, Pope Clement VII name Bishop Simonetta to replace him in the matter of the divorce of Henry VIII of England.
[1] He received the red hat and the titular church of San Ciriaco alle Terme Diocleziane on 31 May 1535.
[1] He was named bishop of Lodi on 4 August 1536, though he later resigned the government of the diocese in favor of his nephew Giovanni Simonetta on 20 June 1537.
[1] In 1539, he was the papal legate to the Council of Vincenza, along with Cardinals Girolamo Aleandro land Bonifacio Ferrero.