Known for his pace, work-rate, and versatility, Mesto usually played as a full-back or as a wide midfielder on the right flank.

In 2012, he moved to Napoli where he remained until the 2014–15 Serie A season, winning a Coppa Italia and the Supercoppa Italiana in 2014.

[4] On 31 December 2015 he signed with Greek side Panathinaikos for one and a half years.

[5] On 1 June 2016, Mesto extended his contract with the club for another year till the summer of 2018.

[6] At international level, Mesto appeared in the Italian under-21 national team which won the 2004 UEFA European Under-21 Championship,[7] and was a member of the under-23 Olympic squad which won the bronze medal at the 2004 Summer Olympics in Athens.