Born in Rome, D'Angelo started his career as a comedian in the mid-1960s, achieving his first successes with the theatrical company "Il Bagaglino".

[2] His career was launched in the mid-1970s, with a series of successful variety shows such as Mazzabubù, C'era una volta Roma, La Sberla, and reached its peak in the following decade, with Drive In, Odiens and Striscia la notizia.

[2][3] D'Angelo died after a short illness on 15 August 2021 at the Gemelli Hospital in Rome, a few days before he turned 85.

The funeral was celebrated on 17 August in the Church of the Artists in Piazza del Popolo in Rome.

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