He is a member of the generation that created the Italian design movement in the late 1950s through the 1960s and is considered to have played a major role in shaping it.
[3] Frattini opened his own professional practice in Milan, after having worked in the office of his teacher and mentor Giò Ponti.
In 1956 he co-founded Associazione per il Disegno Industriale and throughout his career he practiced both industrial design and architecture, focusing mostly on interiors.
A great connoisseur of wood craftsmanship, he forged a long and fruitful professional partnership with the master craftsman from Bovisio Masciago (Milan), Pierluigi Ghianda.
[12] Glassware designed by Gianfranco Frattini for Progetti is in the permanent collection of the Museum of Modern Art[13] and the Boalum lamp (with Livio Castiglioni) produced by Artemide is in the collection of the Smithsonian, Cooper-Hewitt National Design Museum.