At the 1997 Italian local elections, he was candidate as mayor of Palermo for the Pole for Freedoms but was defeated by Leoluca Orlando of the centre-left coalition.

On 12 May 2008, the Council of Ministers appointed Miccichè as Undersecretary of State with responsibility for CIPE (Interministerial Committee for Economic Planning).

Subsequently, he was appointed as Undersecretary of State for Public Administration and Simplification in the Letta government but resigned in August 2013 after that the Supreme Court of Cassation notified the condemnation of Berlusconi.

Despite the double mandate, he did not resign as an MEP until the Supreme Court of Cassation declared him lapsed on 4 September 2018 due to incompatibility with his role as regional deputy.

[3][4] Based on a 2023 investigation, Micciché was seen buying cocaine from his auto blu, chauffeur driven car paid by the taxpayers; he was not prosecuted as he was only a consumer.