In 2006 she earned a First Level Degree in public administration[4] at the Libera Università Maria SS.

[6] In 1994 she joined the Chamber of Deputies as member of the Forza Italia party.

Stefania Prestigiacomo has expressed support for the construction of new nuclear plants in Italy, a country with very limited reserves of fossil fuel and that currently imports (nuclear) electricity from France due to insufficient domestic capacity.

She also authorized the drilling of off-shore oil wells in the Adriatic Sea in the proximity of Tremiti Islands, a natural maritime park.

She is President of the Inter-ministerial Coordination Committee for the fight against Paedophilia (CICLOPE).