Giant Center replaced Hersheypark Arena as the Bears' home venue in 2002.

Giant Center is owned by the Derry Township Industrial and Commercial Development Authority, as much of the money for its construction was provided by the Commonwealth of Pennsylvania.

It is operated by Hershey Entertainment and Resorts Company, with the naming rights owned by the Giant-Carlisle grocery store chain based in Carlisle, Pennsylvania.

In addition to serving as the home arena for the Hershey Bears ice hockey team, Giant Center hosts an annual concert series and attracts well-known entertainers.

Notable events and developments at Giant Center have included: The arena has hosted a number of musical acts, including: Cher, Rush, Trans-Siberian Orchestra, Tim McGraw, ZZ Top, Rod Stewart, Lynyrd Skynyrd, TobyMac, Third Day, Green Day, New Found Glory, Newsboys, Michael W. Smith, Josh Groban, Kelly Clarkson, Elton John, Fall Out Boy, Michael Bublé, Hilary Duff, The Who, Taylor Swift, George Strait, Little Big Town, Brad Paisley, Keith Urban, Justin Moore, Van Halen, Brad Paisley, Delirious?, Eagles, Theory of a Deadman, Mötley Crüe, New Kids on the Block, Jason Aldean, Skillet, Goo Goo Dolls, Meat Loaf, Flo Rida, Korn, Royal Tailor, Tenth Avenue North, Miranda Lambert, Chris August, Carrie Underwood, Fifth Harmony, Selena Gomez, For King & Country, Casting Crowns, Avenged Sevenfold, MKTO, Demi Lovato, Randy Houser, Gaither Vocal Band, Thomas Rhett, Florida Georgia Line, Wiz Khalifa, Alice Cooper, Lady A, Earth, Wind & Fire, Chicago, Charlie Puth, Slipknot, Phil Wickham, Five Finger Death Punch, Unspoken, Danny Gokey, Volbeat, Foreigner, Cheap Trick, Chris Stapleton, Amy Grant, Bethel Music, Social Club Misfits, Matthew West, Natalie Grant, Zach Williams, Tesla, Styx, Why Don't We, Dan + Shay, Ryan Stevenson, Jordan Feliz, Aaron Cole, We Are Messengers, Jon McLaughlin, 2Cellos, Alan Jackson, Kidz Bop, Disturbed, Pentatonix, Post Malone, Swae Lee, James Taylor, Ghost, JoJo Siwa, Toto, Journey, Melanie Martinez, Rick Astley, and Greta Van Fleet.