The northern section surrounds General Grant Grove and other parts of Kings Canyon National Park and is administered by the Hume Lake Ranger District.

The southern section, which includes Long Meadow Grove, is directly south of Sequoia National Park and is administered by the Western Divide Ranger District, surrounding the eastern half of the Tule River Indian Reservation.

In August 2023, gray wolves reappeared at Giant Sequoia National Monument for the first time in more than 100 years.

In October 2006, Federal District Court Judge Charles Breyer found in favor of the plaintiffs and remanded the plan to the U.S. Forest Service "…so that a proper Monument Plan can be developed in accordance with the Presidential Proclamation,… and in compliance with the National Environmental Policy Act (NEPA)…"[citation needed] In January 2008, the Sequoia National Forest published a notice of intent in the Federal Register that they intended to prepare an environmental impact statement and were beginning a year-long collaborative scoping process for development of a new Giant Sequoia National Monument Management Plan.

[2] As of August 2010[update] only one location in the monument, the Generals Highway, is listed on the National Register of Historic Places, but the monument does have several hundred sites that are potentially eligible for the register.