[1] It covers research and large data-sets that result from work in the biomedical and life sciences.

Originally, the journal was co-published by BioMed Central and the Beijing Genomics Institute (BGI).

[5] In order to host the large data-sets the journal covers, GigaScience has built and integrated its own disciplinary repository: GigaDB.

[6] The journal also provides a Galaxy-based platform to analyze data, GigaGalaxy.

The journal has tried to promote the use of Galaxy pipelines as publishable research outputs through its 'Galaxy Series' of articles.