[1] While studying at Capilano University in 2009, Guerrero met her future collaborators, cinematographer Luke Bramley and producer Gordon Cheng.

[5] In 2014, Guerrero contributed to the horror anthology México Bárbaro with her short film Día de los Muertos.

[11][12] A development executive at Warner Bros contacted Guerrero upon viewing El Gigante, which led to Luchagore pitching several ideas, one of which became La Quinceañera.

[16] Her next short, Madre de Dios, starring Tristan Risk, received praise for its design and screened at the 2015 Fantasia International Film Festival.

[25] It features Mia Xitlali and Bertila Damas and held its world premiere at the Morbido Film Festival on October 28.

[37][38][39] In October 2019, Guerrero signed a first-look deal with Blumhouse and was attached to direct an untitled project for Screen Gems, based on the mythology of Santa Muerte.

[41][42] In March 2021, Guerrero was announced to direct Oscar-nominated actress Adriana Barraza in the film Bingo Hell for Amazon Studios.

[43] Guerrero stars and voices Mischa Jackson/Lebron in the animated Peacock series Supernatural Academy based on the Young-Adult fantasy books by Jaymin Eve.

[16][45] She has cited filmmakers Guillermo del Toro, Alfonso Cuarón, Alejandro G. Iñárritu, Robert Rodriguez, and Quentin Tarantino as major influences.