D'Alessio achieved international success with his single "Un cuore malato", a duet with Belgian-Sicilian singer Lara Fabian.

The song was included in both D'Alessio's Made in Italy Brazilian edition (replacing "Un cuore malato" with Lara Fabian) and in Camargo's 2007 Total album.

In a late 2008 interview with Italian Vanity Fair, D'Alessio says that at the beginning of his career from 1992 to 1997 as his fame grew around Napoli, members of various Camorra clans would threaten him to sing at their parties and other festive gatherings.

[2] On 4 March 2010 he debuted as a run of a television program on Rai Uno presenting his first one-man show called "Gigi this is me".

On 14 February 2011 he performed at Radio City Music Hall in New York, the show being aired on Rai Uno on 4 and 11 March.

The concert also received the prize "United States – Italy Friendship Award" by the National Italian American Foundation.

[4] After a year-long break-up, in September 2018, the couple got back together, but on 3 March 2020, through his Instagram profile, the singer announced the end of their relationship.