The real popularity of the village, which later turned into a town, was brought by one of the representatives of Sufism Abdul Khaliq Ghijduwani, who lived in the XII century in the era of the Turkic dynasty of the Kara-Khanids.

In the Battle of Ghazdewan that took place here, Babur was defeated by the Shaybanids, which put an end to Timurid dynasty domination in Transoxiana.

Under Abdullah Khan II in 1578 near Gʻijduvon a bridge of 13 arches was built across the Zarafshon, apparently serving at the same time as a dam to raise the water in the river and divide it into channels.

Many agree that Gʻijduvon was able to cultivate more refined cuisine compared to other parts of the country because it is one of the earliest populated areas in Central Asia.

The city used to have a large Jewish minority who moved to Israel and the United States after the fall of the Soviet Union when economic conditions were difficult.

Gʻijduvon has no higher educational establishments so in order to attend universities the residents travel to Buhkara, Samarkand, Tashkent or other bigger cities.

Gʻijduvon is in the irrigated cotton growing area of Uzbekistan between the Zeravshan River valley and the Shimolii canal.

Historically, the town was famous for its industrious merchants who traveled to other bigger commercial centers and brought various goods to the local market.

Gʻijduvon craftsmen play important role in the local economy and their work is a major attraction for tourists.