On his ATP Tour debut at the 2022 U.S. Men's Clay Court Championships in Houston, Brouwer as a qualifier, made the quarterfinals after defeating Feliciano López and J. J. Wolf.

160 in Rotterdam, Brouwer was promoted from qualifying into the main draw, also as a wildcard, after the withdrawal of Gaël Monfils,[5] where he defeated top-50 player Marc-Andrea Hüsler in the first round.

It was the first time a Dutch duo, Brouwer and Tallon Griekspoor, reached the quarterfinals in singles of the home tournament, since Raemon Sluiter and Sjeng Schalken in 2003.

[9][10] In April 2023, Brouwer repeated his Houston result from 2022, again reaching the quarterfinals after defeating Aleksandar Kovacevic and fourth seed John Isner.

He also qualified for the 2023 Moselle Open as a lucky loser directly into the second round replacing second seed Alex de Minaur after his late withdrawal, but lost to Pierre-Hugues Herbert.

[13] At the 2024 Libéma Open he entered the main draw as a qualifier and defeated Jakub Menšík[14] and fifth seed Adrian Mannarino to reach his first grass court quarterfinal.